Educational Articles
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Collie eye anomaly (CEA), also called “collie eye defect,” is an inherited, developmental disease in dogs in which there is a mutation of the gene that determines the development of the eye. This mutation results in defects of many layers of the back of the eye. The most common sign of CEA is blindness.
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Color dilution alopecia is an autosomal recessive genetic disorder that affects dogs with dilute-colored coats causing hair loss. Some dogs will also be affected by secondary bacterial infections so topical management and pruritus treatments may be needed to improve the dog's comfort. Affected dogs and their relatives should not be bred.
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Dogs are not completely color blind, as they can see yellow and blue, as well as shades of gray. Their eye structure allows them to see better in dim light compared to people. Near-sightedness is common among dogs.
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Dogs can be amazing family members and greatly enrich our lives! Adding a dog to the family is also a serious commitment, and research before choosing a dog will help set the family and the dog up for success. This handout goes over some factors to consider when selecting a dog.
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Genetic (DNA) testing is readily available, whether you are using it for fun to find out what breeds your pet is made up of or if you are looking into possible medical conditions. DNA samples can be collected either from a cheek swab or a blood draw. Knowing which breeds your pet is made up of can help you and your veterinarian prevent or prepare for health issues in the future.
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All dogs evolved from a common ancestor. Humans started breeding dogs for pleasure in the 19th century and this led to an intense diversification of dog species into the nearly 400 breeds recognized today. DNA tests can be performed on mixed-breed dogs to determine their breed ancestry.
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Despite the huge variety in coat color, there are only two basic pigments that determine the color of canines: eumelanin (black) and phaeomelanin (red). All different variations in color are created by these two pigments, which are both forms of melanin. This handout discusses the details of genetics and coat color selection.
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There are multiple methods of inheritance that determine which characteristics (or phenotypes) are displayed by the offspring, including autosomal dominant, autosomal recessive, and sex-linked inheritance. There are also many polygenic traits (i.e., associated with multiple genes) as well as environmental factors that make it much more complicated to predict disease or the likelihood of passing disease onto offspring.
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Mutations are errors made during DNA replication. Mutations can be acquired as cells divide within the body or can be inherited if the parent's DNA contains a mutation. Genetic markers can be used to determine genetic heritage such as breed origins.
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Deoxyribonucleic acid (DNA) is a long molecule that contains an animal’s entire genetic code. DNA is primarily located within the nucleus of each cell. In the nucleus, enzymes transcribe the DNA bases into a substance called RNA (ribonucleic acid), which serves as a messenger, taking the DNA message out into the cytoplasm of the cell where the RNA is translated into proteins. These proteins are responsible for a number of functions in the cell and throughout the body, primarily by acting as enzymes that regulate various cell reactions. DNA tests allow us to examine an animal’s DNA in order to see whether they carry certain genetic diseases. DNA testing can also be used to determine the ancestry of an animal.
